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Sample text

If this sounds bleak to you, you get the picture. As you might expect, depression affects 40 to 50 percent of patients with Parkinson’s disease. Anxiety, loss of interest, and various physical complaints often go along with the depressed mood. 6 When I see one of these unfortunate patients in my practice, I always feel a strong desire to help them get better. The depression that afflicts those with Parkinson’s disease shares important similarities with depression in patients who have had a stroke or have Alzheimer’s.

Unlike diseases affecting other body parts, brain diseases affect speech, coordination, movement, walking, and sensation. Tremors, tics, spasms, slurred speech, disfigurement, disability, dependence, and other effects of brain diseases make life even harder for many patients. Under such circumstances, sadness, worry, embarrassment, 34 B E AT DE PRESSION TO STA Y HEA LTHIER A ND LIVE LONGER discouragement, and anger seem natural and can evolve into depression. The second way brain diseases bring out more depression is by directly weakening coping abilities.

A process that is not yet fully understood stresses neurons to the point that they wither and die. This process probably begins in middle age but goes unnoticed for many years. As more and more brain cells die, brain circuits start to malfunction. Once this happens, the functions these circuits perform start to fail and symptoms appear. Alzheimer’s disease characteristically affects some areas of the brain earlier than others, but there is some variation from person to person. The short-term memory centers are usually the first to go, and this is why forgetfulness is generally the earliest symptom.

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