By C. Caux, B. Vanbervliet, C. Massacrier, B. Dubois, C. Dezutter-Dambuyant, D. Schmitt (auth.), Dr. Jacques Banchereau, Dr. Daniel Schmitt (eds.)
These lawsuits comprise the contributions of the members of the 3rd overseas Symposium on Dendritic Cells that used to be held in Annecy, France, from June 19 to June 24, 1994. This symposium represented a follow-up of the 1st and moment overseas symposia that have been held in Japan in 1990 and within the Netherlands in 1992. Dendritic cells are antigen-presenting cells, and are present in all tissues and organs of the physique. they are often categorized into: (1) interstitial dendritic cells of the center, kidney, intestine, and lung;(2) Langerhans cells within the pores and skin and mucous membranes; (3) interdigitating dendritic cells within the thymic medulla and secondary lymphoid tissue; and (4) blood dendritic cells and lymph dendritic cells (veiled cells). even though dendritic cells in every one of those booths are all CD45+ leukocytes that come up from the bone marrow, they might express variations that relate to maturation nation and microenvironment. Dendritic cells are really expert antigen-presenting cells for T lymphocytes: they approach and current antigens successfully in situ, and stimulate responses from naive and reminiscence T cells within the paracortical region of secondary lymphoid organs. fresh facts additionally demonstrates their function in induction of tolerance. in contrast, the first and secondary B-cell follicles comprise follicular dendritic cells that catch and hold intact antigen as immune complexes for lengthy classes of time. The beginning of follicular dendritic cells isn't transparent, yet so much investigators think that those cells will not be leukocytes.
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Extra info for Dendritic Cells in Fundamental and Clinical Immunology: Volume 2
Tertappen. Control of lymphocyte rectrculatton m man I Dtfferentlal regulation of the penpheral lymph node hotnlng receptor Lselectm on T cell dunng the VIrgin to memory cell tranSItion J Immunol 150 1105 (1993) 37 IMMORTALIZED MURINE DENDRITIC CELLS: PHENOTYPIC AND FUNCTIONAL CHARACTERIZATION Geoffrey Rowden, Shirley Dean and Pat Colp Pathology Department Dalhousie University Halifax, Nova Scotia, B3H 4H7, Canada INTRODUCTION Problems with the isolation of pure populations of dendritic cells (DC) have hindered investigations of their various functional attributes.
The results also suggest that thymic DC could be of lymphoid rather than myeloid origin, which would accord with their expression of certain lymphoid markers. Since the thymic precursor cells also form CD8a+ DC in the spleen if transferred intravenously (Wu, experiments in progress), these precursors may give rise to a distinct sublineage of DC. Such a lineage would be concentrated in the thymus but would also be found in other lymphoid organs. However, clonal evidence is needed to establish if these CD8a+ DC differ in origin from "myeloid" DC.
Pierani, A. Boglia, G. De Libero, L. Mori, V. Marini and P. Ricciardi-Castagnoli, Generation of new oncogenic retroviruses by cotransfection of cloned AKR and MH2 provirus, Oncogene 4:223 (1989). 2. M. Righi, L. Mori, G. De Libero, A. Sironi, A. Biondi, A. D. Donini, and P. Ricciardi-Castagnoli, Monokine production by microglial cell clones, Eur. 1. lmmunol. 19: 1443 (1989). 3. P. Riccardi-Castagnoli and P. Paglia, New tools for investigating macrophage differentiation, Res. lmmunol. 143: 101 (1992).