Download Clinical Neuroimmunology: Multiple Sclerosis and Related by Patricia K. Coyle MD (auth.), Syed A. Rizvi, Patricia K. PDF

By Patricia K. Coyle MD (auth.), Syed A. Rizvi, Patricia K. Coyle (eds.)

Clinical Neuroimmunology: a number of Sclerosis and similar problems serves as an fundamental source for physicians drawn to, and working with, this very complicated and evolving department of neurology. This accomplished titleprovides an creation to simple neuroimmunology and rules of immunotherapy and in addition serves as an intensive advisor to immune-mediated issues of the valuable and peripheral frightened process, in addition to different systemic issues with an important neuroimmunologic part. The chapters are written via specialists of their fields and contain the freshest medical info. This quantity is made to simplify advanced immunological mechanisms and to target useful patient-related concerns. Clinical Neuroimmunology: a number of Sclerosis and similar issues is a useful addition to the literature and should be of vital curiosity toneurologists, citizens and fellows, internists, and normal practitioners who deal with sufferers with neurologic problems and different systemic autoimmune diseases.

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Semin Immunopathol. 2009;31:439–53. Barnett MH, Prineas JW. Relapsing and remitting multiple sclerosis: pathology of the newly forming lesion. Ann Neurol. 2004;55:458–68. Parratt JDE, Prineas JW. Neuromyelitis optica: a demyelinating disease characterized by acute destruction and regeneration of perivascular astrocytes. Mult Scler. 2010;16:1156–72. Henderson APD, Barnett MH, Parratt JDE, et al. Multiple sclerosis. Distribution of inflammatory cells in newly forming lesions. Ann Neurol. 2009;66:739–53.

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This increased energy demand, along with mitochondrial dysfunction, leads to axonal hypoxia [126]. This appreciation of ion channel changes has led to voltage-gated sodium channel blockade being proposed as a strategy to treat MS [127]. Acute axonal injury is prominent in active inflammatory plaques and correlates with inflammation (CD8+ T cells, macrophages, microglia) [12, 25]. Axonal injury does not require demyelination. Retinal nerve fiber layer, made up of unmyelinated axons, can be evaluated by optical coherence tomography, and shows deficits in MS [128].

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