By Joseph Jankovic
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Additional resources for Clinical Insights: Parkinson's Disease: Medical and Surgical Treatment
The 2 mg/day dose may have provided sufficient symptomatic improvement to mask a potential disease-modifying effect of this dose. 3. Proposed algorithm for early treatment of Parkinson’s disease. COMT: Catechol-O-methyltransferase; DA: Dopamine agonist; DBS: Deep-brain stimulation; MAO-BI: Monoamine oxidase type B inhibition; PD: Parkinson’s disease. of these MAO-B inhibitors. Longterm results of the ADAGIO trial may provide further evidence of rasagiline’s potential for disease modification. These medications require further study to understand their potential long-term benefits.
Com Prevention & management of levodopa-related motor complications due to the postoperative reduction in dopaminergic medications [36–38] . While gait can improve after DBS, FOG has not been shown to improve to the extent of other ‘off’ state features and the benefits that may occur tend to be short lived  . DBS for ‘on’ state FOG has not been shown to be effective, although it may allow the reduction of dopaminergic medications without worsening other parkinsonian features. It is important to note that PD patients are candidates for DBS if their response to levodopa remains excellent (even if for brief periods within each dose cycle), their cognitive function is preserved, and any psychiatric complication is controlled.
20(3), 342–344 (2005). com 6. Jankovic J. Motor fluctuations and dyskinesias in Parkinson’s disease: Clinical manifestations. Mov. Disord. 20(Suppl. 11), S11–S16 (2005). 7. Nutt JG, Fellman JH.