By Gary J. Schiller
In persistent Leukemias and Lymphomas: scientific administration, a panel of famous specialists in hematological oncology describe the original organic beneficial properties of indolent hematologic neoplasms, supplying strong perception into their medical manifestation, highlighting capability pursuits for novel remedies, and distinguishing those issues from competitive lymphoma and Hodgkin's affliction. of their built-in surveys of those continual myeloproliferative and lymphoproliferative problems, the authors emphasize such precise entities as prolymphocytic leukemias and cutaneous lymphomas. detailed emphasis is given to the mechanisms of ailment development with authoritative insights into the promising new period of antineoplastic pharmacology.
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Extra resources for Chronic Leukemias and Lymphomas: Clinical Management (Current Clinical Oncology)
Usually p53 mutations accompany 17p deletions, are found in 12–25% of cases of CLL, and are strongly associated with advanced disease and Richter’s transformation (27). ATM is another gene that may function as a classical tumorsuppressor gene in CLL. ATM is located at 11q22-11q23, which is the region deleted in CLL. Inherited homozygous ATM mutations result in ataxia telangiectasia, which is itself associated with a greatly increased risk of lymphoid neoplasia and acquired homozygous ATM mutations are also known to occur in T-PLL.
J Am Med Assoc 1983;250: 620–624. 115. Robinette CD, Jablon S, Preston TL. Mortality of nuclear weapons test participants medical follow up Agency. National Research Council Washington DC, National Academy Press, 1985. 116. Milham S. Mortality from leukemias in workers exposed to electrical and magnetic fields. N Engl J Med 1982;307:249. 117. Pearce N, Reif J, Fraser J. Case-control studies of cancer in New Zealand electrical workers. Int J Epidemiol 1989;18:55–59. 118. Tynes T, Andresen A, Landmark F.
The second is a malignancy of somatically mutated memory B-cells, and is associated with a significantly more favorable outcome. It seems highly Chapter 2/Chronic Lymphocyte Leukemia 27 Table 2 Chromosomal Abnormalities in CLL as Detected by Conventional Metaphase Cytogenetics Abnormality Frequency Trisomy 12 33% Del 13q 15% Del 11q23 11% Del 6q t(11;14) 5% 2% Comments Atypical cytology Poor outcome Similar prognosis to cases with normal karyotype Extensive lymphadenopathy Poor prognosis Deletions may occur at sites of CCG trinucleotide repeats Probably cases of MCL likely that these striking differences in prognosis will in turn relate to the presence of other established genetic abnormalities such as p53 or ataxia telangiectasia mutated gene (ATM) inactivation.