By Liv Storstein (auth.), Professor Dr. med. Kurt Greeff (eds.)
The pharmacokinetics of digitalis glycosides were the topic of intensive re view (IISALO, 1977; ARONSON, 1980; PERRIER et ai., 1977). learn on glycoside kinetics has advanced at a swift speed, requiring carrying on with reevaluation of the country of our knowing of this challenge. the current article makes a speciality of the impact of illness states (renal, gastrointestinal, thyroid, and cardiac) at the absorption, distribution, and clearance of a few digitalis glycosides. facts is significantly reviewed, and interpreted with appreciate to attainable scientific implications. A. Renal Insufficiency I. Strophanthin Strophanthin disposition in renal failure has been evaluated in just stories. KRAMER et ai. (1970) made up our minds an removal half-life of 14 h in normals as com pared to 60 h in anuric sufferers. related effects have been said via BRASS and Pm LIPPS (1970) utilizing tritiated strophanthin. they discovered a half-life price of 18 h in fit contributors in comparison to sixty eight h in anuric sufferers. The findings truly in dicate that the removal half-life of strophanthin is lengthy in renal failure.
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Extra resources for Cardiac Glycosides: Part II: Pharmacokinetics and Clinical Pharmacology
No significant difference in serum elimination half-life was found by KRAMER et aI. (1970) after administration of radiolabeled digitoxin intravenously to four patients on hemodialysis and one on peritoneal dialysis (Table 4). Serum concentrations on maintenance dosage are lower in patients on hemodialysis than in control patients as can be seen from Table 5. 9% in the control group (STORSTEIN, 1977 a; STORSTEIN and AMLIE, 1977 b). The extent of conjugation was the same in hemodialysis and control patients and only minor changes were found in the pattern of cardioactive metabolites in urine in comparison with the control group.
XI. Digitoxin metabolism in patients with impaired renal function. Clin. Pharmacol. Ther. : Studies on digitalis. IX. Some kinetic aspects of digitoxin metabolism. Clin. Pharmacol. Ther. : Studies on digitalis. XII. Kinetic pattern of digitoxin metabolism in patients with biliary fistulas. Clin. Pharmacol. Ther. : Digitoksin i klinisk bruk. T. norske Legeforen. : Pharmacokinetics and metabolism in patients with chronic active hepatitis. In: Digitoxin als Alternative in der Therapie der Herzinsuffizienz.
Entgiftungsgeschwindigkeit und Kumulation von Digitoxin bei verschiedenen Species. Naunyn-Schmiedebergs Arch. Pharmacol. : Speciesunterschiede in der Biotransformation von Digitoxin. Naunyn-Schmiedebergs Arch. Pharmacol. : Konjugation von Cardenolidgeninen mit Schwefelsaure oder Glucuronsaure. Naunyn-Schmiedebergs Arch. Pharmacol. : Epimerisierung und Hydroxylierung von digitaloiden Steroidlactonen durch Fermente der Leber. Naunyn-Schmiedebergs Arch. Pharmacol. : The pharmacokinetics of 3H-digitoxin and its metabolites in the guinea-pig.