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By Professor Dr. med. Helmut Löffler, Professor Dr. med. Johann Rastetter, Professor Dr. med. Dr. phil. T. Haferlach (auth.)

This sixth variation of the atlas has built-in the 2001 WHO class and made use of figures and outlines to rfile lately defined kinds of leukemia and lymphoma. The latter contain leukemias of dendritic cells, infrequent lymphomas and protracted polyclonal B lymphocytosis, which takes a different position within the classification.

The quantity covers all of the microscopic tools in hematology that shape the foundation of prognosis in addition to the result of smooth immunologic, cytogenetic and molecular-genetic research. specific emphasis is put on the cytogenetic and molecular-genetic characterization of organic entities that would shape the root for cutting edge therapies.

Normal effects and pathological findings are in comparison, and a number of the findings made in the course of remedy are depicted. All in all of the Atlas of scientific Hematology represents a whole and beneficial reference paintings which might be found in each hematologic and oncologic division in addition to in scientific laboratories for on-line diagnostics and clinical research.

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10 d – f) Here the granulocytes contain large, bluish granules that often resemble those of promyelocytes; monocytes have large granules, too. The abnormal granulation is especially marked in eosinophils, which appear basophilic rather than eosinophilic (Fig. 10 e, left). The lymphocytes also contain particularly large azurophilic granules (Fig. 10 f). Carriers of this anomaly frequently have associated bone and joint deformities (gargoylism). The anomaly is known to occur in mucopolysaccharidosis VI and VII.

As myelomonoblasts. They range from 12 to 20 lm in diameter (Fig. 7 a – c). The cytoplasmic rim is basophilic but may show a range of hues from soft pale blue to dark blue. The cytoplasm is agranular on ordinary panoptic staining, although older cells frequently show incipient granulation signifying transition to the promyelocyte stage (Fig. 7 d). The peroxidase reaction is usually negative, but there is no question that agranular, peroxidase-positive myeloblasts exist. The nucleus shows a very fine, dense chromatin structure with as many as six nucleoli, which generally are distinct and pale blue.

This is especially common in pernicious anemia but is not pathognomonic for that condition. The band and segmented forms range from 10 to 15 lm in size. Eosinophilic granulocytes (Fig. 8 b, e, f) develop in much the same way as neutrophils, but the two cell types are always distinguishable from the promyelocyte stage onward. The nuclei have struc- tures similar to the corresponding maturation stages. The typical large eosinophilic granules almost completely obscure the cytoplasm. Conspicuously large granules, sometimes of a deep blue color, may be found among these mature eosinophilic granules in the early stages of promyelocytes and myelocytes (Fig.

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