By Lesley McGee, Keith P. Klugman (auth.), Douglas L. Mayers MD (eds.)
The volumes incorporated in Antimicrobial Drug Resistance symbolize the 1st entire, multidisciplinary reference masking the world of antimicrobial drug resistance in micro organism, fungi, viruses, and parasites from uncomplicated technological know-how, medical, and epidemiological perspectives.
The first quantity, Antimicrobial Drug Resistance, Mechanisms of Drug Resistance, is devoted to the organic foundation of drug resistance and potent avenues for drug improvement. With the emergence of extra drug-resistant traces, the method of facing the drug resistance challenge needs to contain the examine of other elements of the mechanisms of bacterial resistance and the dissemination of resistance genes in addition to study using new genomic info. those techniques will allow the layout of novel thoughts to increase new antibiotics and guard the effectiveness of presently to be had ones.
The moment quantity, Antimicrobial Drug Resistance, medical and Epidemiological Aspects, is dedicated to the medical features of drug resistance. even supposing there's proof that constrained use of a selected antibiotic should be by means of a lessen in drug resistance to that agent, drug resistance keep an eye on isn't simply completed. therefore, the infectious affliction health care professional calls for enter from the scientific microbiologist and an infection keep an eye on expert to make knowledgeable offerings for the potent therapy of varied traces of drug-resistant pathogens in person patients.
This 2-volume set is a crucial reference for college students in microbiology, infectious disorder physicians, clinical scholars, simple scientists, drug improvement researchers, microbiologists, epidemiologists, and public future health practitioners.
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Additional info for Antimicrobial Drug Resistance: Clinical and Epidemiological Aspects
Klugman KP, Friedland IR. Antibiotic-resistant pneumococci in pediatric disease. Microb Drug Resist 1995;1:5–8 8. Bronzwaer S, Cars O, Buchholz U, et al. A European Study on the relationship between antimicrobial use and antimicrobial resistance. Emerg Infect Dis 2002;8:278–282 9. Arason VA, Kristinsson KG, Sigurdsson JA, Stefansdottir G, Molstad S, Gudmundsson S. Do antimicrobials increase the carriage rate of penicillin resistant pneumococci in children? Cross sectional prevalence study. Br Med J 1996;313:387–391 10.
Have found that 20% of the VGS blood isolates of neutropenic cancer patients can have imipenem MIC of 1 mg/L or more (31). Similarly, Diekema et al. 5 mg/L (29). The problem with imipenem is that there are no NCCLS breakpoints for non-pneumococcal streptococci (44). Streptococci are in vitro highly susceptible to another carbapenem compound, meropenem. Only few resistant strains with MICs as high as 2 mg/L have been found (46). 2 Resistance to Macrolides, Lincosamides and Ketolides Macrolides, ketolides, lincosamides and streptogramin B antibiotics, although having different kind of chemical structure, all have similar although not identical antimicrobial activity against VGS.
Both of these enzymes are important for cell wall synthesis, but only the high-molecular-weight PBPs are important for the bacterial killing activity of the beta-lactam antibiotics (19). In VGS there are two kind of high-molecular-weight PBPs: PBP1 (PBP1a and PBP1b) and PBP2 (PBP2a, PBP2b, PBP2x) (20). Homologous molecules can be found from S. pneumoniae and naming conventions for PBPs of the VGS are adapted from S. pneumoniae (19–21). VGS with wild-type PBSs are susceptible to beta-lactam antibiotics (22).