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By C. Wüster, T. Cowell

Complement factor: Hormone study 2000, Vol. fifty four, No. 1

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The system used cone-beam geometry and a three-dimensional reconstruction algorithm. The spatial resolution of 60 Ìm achieved clearly visualized individual trabeculae, allowing a three-dimensional analysis of the trabecular network. Goulet et al. [22] utilized images of bone cubes generated by this system to examine standard histomorphometric parameters, as well as additional parameters such as the Euler number (an index of connectivity) and mean intercept length (a means of determining an isotrophy).

300 Ìm, and compared these images with XTM images and with serial grindings to determine the impact of in-plane resolution and slice thickness on both two- and three-dimensional structural and textural parameters. Considerable resolution dependence was observed for traditional stereological parameters, some of which could be modulated by appropriate thresholds and image processing techniques. Limitations of the signal-to-noise ratio, spatial resolution and total imaging time prevent resolution of smaller individual trabeculae in vivo at clinical field strengths, but the images show the larger trabeculae and the texture of the trabecular network.

The data show that patients in KIMS are at a higher risk of fracture than healthy individuals in EVOS. 7-fold) is similar to that reported in the two published studies. The results of the KIMS versus EVOS analysis are based on a subgroup of 264 KIMS patients with a similar mean age to the EVOS participants (approximately 65 years), but the prevalence of fractures in this subgroup was similar to that in all KIMS patients. This finding suggests that adults of all ages with hypopituitarism and GHD are more likely to experience a fracture than the general population.

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